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Cell Cycle & DNA Repair Research Laboratory

thomas caspari

Why do we get cancer?

My research group tries to find answers to why normal cells turn malignant by studying how our genetic information changes over time. Many of the key events which alter the DNA occur when cells copy their chromosomes. During this process the DNA must be opened up which makes it vulnerable to breakage and chemical modifications.

We use the fission yeast (Schizosaccharomyces pombe) and human cells to research diverse pathways ranging from cell cycle regulators to DNA damage checkpoints to the circadian clock, all working together to prevent these genetic aberrations.

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